THAPAR, Nikhil; SANDERSON, Ian R. Diarrhoea in children: an interface between developing and developed countries. The Lancet, London, v. 363, n. 9409, p. 641-653, 21 Feb. 2004. (Texto completo indisponível).
Despite much progress in the understanding of pathogenesis and of management, diarrhoeal illness remain one of the most important causes of global childhood mortality and morbidity. Infections account for most illnesses, with pathogens employing ingenious mechanisms to establish disease. In the developed world, an upsurge in immunemediated gut disorders might have resulted from a disruption of normal bacterial-epithelial cross-talk and impaired maturation of the gut’s immune system. Preventive strategies on a global scale might ultimately hold the greatest potential to reduce the burden of diarrhoeal disease. These strategies include vaccines and, most importantly, policies to address persisting inequalities between the developed and developing worlds with respect to nutrition, sanitation, and access to safe drinking water.